2,4-Difluorophenylglyoxal hydrate → as-Triazine, 5-(2,4-difluorophenyl)-3-(methylthio)-

反応式

[NH:1]([C:3]([S:5][CH3:6])=[NH:4])[NH2:2].O.[F:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[C:16]([CH:18]=O)=O>>[CH3:6][S:5][C:3]1[N:1]=[N:2][CH:18]=[C:16]([C:10]2[CH:11]=[CH:12][C:13]([F:15])=[CH:14][C:9]=2[F:8])[N:4]=1

参加物

反応物 2

HCID 27823002,4-Difluorophenylglyoxal hydrate

HCID 178504051Methyl hydrazinecarbimidothioate

生成物 1

HCID 3053040as-Triazine, 5-(2,4-difluorophenyl)-3-(methylthio)-収率 78%

実験手順

3-(Methylsulfanyl)-5-(2,4-difluorophenyl)-1,2,4-triazine (1.00 g, 78%) was prepared from methyl hydrazinecarbimidothioate (0.63 g, 6.0 mmol) and 2,4-difluorophenylglyoxal monohydrate (1.00 g, 6.0 mmol) according to the general procedure of Preparation 2.

後処理

customaccording to the general procedure of Preparation 2

出典と根拠

ORDレコード: ord-19e9a95df52b4444833f118177382581
出典データセット: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08809525B2

反応ノート

読み込み中…