Propargyl alcohol → [3-(2-Chlorophenyl)-1,2-oxazol-5-yl]methanol

HRID 2407657ノート

反応式

HRID 2407657 の反応式
C(N(CC)CC)C.[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15](Cl)=[N:16][OH:17].[CH2:19]([OH:22])[C:20]#[CH:21]>C(OCC)C>[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:21]=[C:20]([CH2:19][OH:22])[O:17][N:16]=1

参加物

5

反応物 3

HCID 7859Propargyl alcoholHCID 8471TriethylamineHCID 38097332-Chloro-N-hydroxy-benzamidine

生成物 1

HCID 1471845[3-(2-Chlorophenyl)-1,2-oxazol-5-yl]methanol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A solution of triethylamine (48 mL) in diethyl ether (0.5 L) was added over two hours to a 0° C. solution of the compound prepared in Example 5 (50.0 g) and propargyl alcohol (31 mL) in diethyl ether (1.2 L). The reaction was stirred at room temperature overnight, washed with water, dried over anhydrous magnesium sulfate and concentrated to obtain the title compound (50.0 g) having the following physical data.

後処理

  1. washwashed with water
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-c57dba5bcf7c45099b8755f5405620f7
出典データセット
uspto-grants-2014_08
特許番号
US08809538B2

反応ノート

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