2-Chloronicotinic acid → 2-Ethoxypyridine-3-carboxylic acid

HRID 2407767ノート

反応式

HRID 2407767 の反応式
[O-:1][CH2:2][CH3:3].[Na+].Cl[C:6]1[N:14]=[CH:13][CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9]>C(O)C>[CH2:2]([O:1][C:6]1[N:14]=[CH:13][CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9])[CH3:3]

参加物

4

反応物 2

HCID 762582-Chloronicotinic acidHCID 2723922Sodium ethoxide

生成物 1

HCID 27363452-Ethoxypyridine-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
170 °C

実験手順

A solution of sodium ethoxide (14.2 mL) was added to a solution of 2-chloronicotinic acid (2.00 g) in ethanol (13 mL). The mixture was heated in a sealed vessel at 170° C. for 2 days. After cooling, the mixture was concentrated in vacuo and the residue taken in water and acidified with hydrochloric acid to pH 3. The precipitated solids were collected by filtration and washed with water to obtain the title compound (1.32 g) having the following physical data.

後処理

  1. temperatureAfter cooling
  2. concentrationthe mixture was concentrated in vacuo
  3. filtrationThe precipitated solids were collected by filtration
  4. washwashed with water

出典と根拠

ORDレコード
ord-dc62b7633eaa408eb8d62e494388d43c
出典データセット
uspto-grants-2014_08
特許番号
US08809538B2

反応ノート

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