HCID 58504050、化合物 → 1-(2-pyridin-2-yl-1,3-thiazol-5-yl)ethanone

HRID 2407797ノート

反応式

HRID 2407797 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:8][C:9]([CH:12]([OH:14])[CH3:13])=[CH:10][N:11]=1>ClCCl.[O-2].[Mn+4].[O-2]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:8][C:9]([C:12](=[O:14])[CH3:13])=[CH:10][N:11]=1

参加物

4

反応物 1

HCID 58504050HCID 58504050、化合物

生成物 1

HCID 27682031-(2-pyridin-2-yl-1,3-thiazol-5-yl)ethanone収率 94.9%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

The compound prepared in Example 357 (2.5 g) was dissolved in 80 mL of dichloromethane and manganese (IV) oxide (21 g) was added stirred overnight at room temperature. The reaction mixture was filtered through a plug of Celite (trade mark), washed with dichloromethane, and concentrated under reduced pressure to afford the title compound (2.35 g) having the following physical data. 1H NMR (CDCl3): δ 8.64 (d, J=4.5 Hz, 1H), 8.39 (s, 1H), 8.22 (d, J=7.9 Hz, 1H), 7.83 (m, 1H), 7.39 (m, 1H), 2.62 (s, 3H).

後処理

  1. filtrationThe reaction mixture was filtered through a plug of Celite (trade mark)
  2. washwashed with dichloromethane
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-e57a1c6a15e548039db900719452fcdb
出典データセット
uspto-grants-2014_08
特許番号
US08809538B2

反応ノート

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