Cyclopropanemethanol → HCID 58504038、化合物

反応式

[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6](Cl)[N:5]=[C:4]([C:11]([NH:13][CH2:14][CH:15]2[CH2:20][CH2:19][N:18]([CH2:21][C:22]3[S:26][C:25]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[F:33])=[N:24][CH:23]=3)[CH2:17][CH2:16]2)=[O:12])[CH:3]=1.[CH:34]1([CH2:37][OH:38])[CH2:36][CH2:35]1>>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:38][CH2:37][CH:34]2[CH2:36][CH2:35]2)[N:5]=[C:4]([C:11]([NH:13][CH2:14][CH:15]2[CH2:20][CH2:19][N:18]([CH2:21][C:22]3[S:26][C:25]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[F:33])=[N:24][CH:23]=3)[CH2:17][CH2:16]2)=[O:12])[CH:3]=1

参加物

反応物 2

HCID 75644Cyclopropanemethanol

HCID 58503938HCID 58503938、化合物

生成物 1

HCID 58504038HCID 58504038、化合物

実験手順

According to the same procedure described in Example 204, using the compound prepared in Example 393 instead of the compound prepared in Example 215 and cyclopropylmethanol instead of 1-cyclopropylethanol, the title compound having the following physical data was obtained.

出典と根拠

ORDレコード: ord-ca51a781f55c498c8d57f746a3996395
出典データセット: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08809538B2

反応ノート

読み込み中…