Water → Methyl 4-amino-5,6-dichloropicolinate
反応式
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]([O:11][CH3:12])=[O:10])[CH:3]=1.[Cl:13]N1C(=O)CCC1=O.C(=O)(O)[O-].[Na+].O>CN(C)C=O>[NH2:1][C:2]1[C:7]([Cl:13])=[C:6]([Cl:8])[N:5]=[C:4]([C:9]([O:11][CH3:12])=[O:10])[CH:3]=1参加物
6
反応条件
- 温度
- 50 °C
実験手順
The compound prepared in Example 404 (3.120 g) and N-chlorosuccinimide (2.456 g) were suspended in dimethyl formamide (100 mL) and stirred at 50° C. overnight. The reaction mixture was heated at 70° C. for a further 3 hours. The reaction mixture was added drop-wise to a stirred solution of 1:1 saturated aqueous sodium bicarbonate and water. The slurry was filtered and the solids dried under high vacuum to furnish the title compound (2.438 g), possessing the following physical data.
後処理
- temperatureThe reaction mixture was heated at 70° C. for a further 3 hours
- filtrationThe slurry was filtered
- customthe solids dried under high vacuum
出典と根拠
- ORDレコード
- ord-93104871107f402da7d82396c220118d
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08809538B2
反応ノート
読み込み中…