Phenol → 4-Methoxy-2-phenoxynicotinonitrile

HRID 2407827ノート

反応式

HRID 2407827 の反応式
Cl[C:2]1[N:9]=[CH:8][CH:7]=[C:6]([O:10][CH3:11])[C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[Cs+].[Cs+].[C:18]1([OH:24])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CC(N(C)C)=O.O>[CH3:11][O:10][C:6]1[C:3]([C:4]#[N:5])=[C:2]([O:24][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:9]=[CH:8][CH:7]=1

参加物

6

反応物 3

HCID 996PhenolHCID 10796Cesium carbonateHCID 14709302-Chloro-4-methoxynicotinonitrile

生成物 1

HCID 14843434-Methoxy-2-phenoxynicotinonitrile収率 70.4%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 31374Dimethylacetamide溶媒

反応条件

温度
75 °C

実験手順

A solution of 2-chloro-4-methoxynicotinonitrile (1.02 g) in dimethylacetamide (30 mL) was treated with cesium carbonate (2.96 g) followed by phenol (0.683 g) at room temperature. The mixture was heated to 75° C. overnight. The mixture was cooled to room temperature, diluted with water (100 mL) and the precipitated solids collected by filtration, to provide the title compound (0.964 g) with the following physical data.

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe precipitated solids collected by filtration

出典と根拠

ORDレコード
ord-8d5421dd4a6348a785c1ad852bfeac4f
出典データセット
uspto-grants-2014_08
特許番号
US08809538B2

反応ノート

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