Dimethylformamide dimethyl acetal → 6-(2-(Dimethylamino)vinyl)-2-ethoxy-5-nitronicotinonitrile
反応式
[CH2:1]([O:3][C:4]1[N:11]=[C:10]([CH3:12])[C:9]([N+:13]([O-:15])=[O:14])=[CH:8][C:5]=1[C:6]#[N:7])[CH3:2].CO[CH:18](OC)[N:19]([CH3:21])[CH3:20]>CN(C)C=O>[CH3:18][N:19]([CH3:21])[CH:20]=[CH:12][C:10]1[C:9]([N+:13]([O-:15])=[O:14])=[CH:8][C:5]([C:6]#[N:7])=[C:4]([O:3][CH2:1][CH3:2])[N:11]=1参加物
4
実験手順
To a stirred solution of the compound prepared in Example 444 (0.86 g) in N,N-dimethylformamide (10 mL) at ambient temperature was added N,N-dimethylformamide dimethyl acetal (94%, 0.65 mL). The resulting solution was stirred and heated to reflux for 30 minutes. After cooling to ambient temperature, the solution was concentrated to provide the title compound (1.07 g) with the following physical data.