Benzene → (4E)-2,4-dimethyl-5-phenyl-4-pentenal
反応式
C([O:4][CH2:5]/[C:6](/[CH3:14])=[CH:7]/[C:8]1[CH:13]=CC=C[CH:9]=1)C=C.[CH:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH3:14][CH:6]([CH2:7]/[C:8](/[CH3:13])=[CH:9]/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH:5]=[O:4]参加物
3
実験手順
The (1E)-[3-(allyloxy)-2-methyl-1-propenyl]benzene (107.79 g, 0.571 mol), [RuCl2(PPh3)3] (3.13 g), BHT (1 g) and benzene (500 ml) were heated together in an autoclave in an oil bath at 190° C. for 4 hours. After cooling to room temperature, solvents were evaporated and the product purified by column chromatography on silica gel (eluent: heptanes/ethyl acetate 10:1) followed by bulb-to-bulb distillation (88° C./0.009 mbar) to give 11.21 g of the desired compound (0.060 mol, 10%).
後処理
- customsolvents were evaporated
- customthe product purified by column chromatography on silica gel (eluent: heptanes/ethyl acetate 10:1)
- distillationfollowed by bulb-to-bulb distillation (88° C./0.009 mbar)
出典と根拠
- ORDレコード
- ord-091e91c37da045819fed165a702cda8f
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08815792B2
反応ノート
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