Morpholine → 1-(2-isopropoxyethyl)-2,2-dimethyl-7-(morpholin-4-yl)-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one

HRID 2408334

反応式

HRID 2408334 の反応式
Cl[C:2]1[N:3]=[C:4]2[N:11]([CH2:12][CH2:13][O:14][CH:15]([CH3:17])[CH3:16])[C:10]([CH3:19])([CH3:18])[CH2:9][N:5]2[C:6](=[O:8])[CH:7]=1.[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[CH:15]([O:14][CH2:13][CH2:12][N:11]1[C:4]2=[N:3][C:2]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[CH:7][C:6](=[O:8])[N:5]2[CH2:9][C:10]1([CH3:19])[CH3:18])([CH3:17])[CH3:16]

参加物

3

反応物 2

HCID 8083MorpholineHCID 680345397-chloro-1-(2-isopropoxyethyl)-2,2-dimethyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one

生成物 1

HCID 573895331-(2-isopropoxyethyl)-2,2-dimethyl-7-(morpholin-4-yl)-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one収率 60%

実験手順

150 mg of 7-chloro-1-(2-isopropoxyethyl)-2,2-dimethyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one in 2 mL of morpholine are heated with the microwave oven to 80° C. for 45 mins. The crude is purified by flash chromatography on silica gel (CH2Cl2 100% to CH2Cl2/MeOH, 92/8). 0.085 g (yield=60%) of 1-(2-isopropoxyethyl)-2,2-dimethyl-7-(morpholin-4-yl)-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one are obtained as a beige solid and including the following characteristics:

後処理

  1. customThe crude is purified by flash chromatography on silica gel (CH2Cl2 100% to CH2Cl2/MeOH, 92/8)

出典と根拠

ORDレコード
ord-f23b64a8af494820b1c2b28a1bbce753
出典データセット
uspto-grants-2014_08
特許番号
US08815853B2

関連ノート

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