(1-Methyl-1H-benzimidazol-5-yl)boronic acid → HCID 86720132、化合物
反応式
[CH3:1][O:2][C:3](=[O:26])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([OH:25])[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.[CH3:27][N:28]1[C:32]2[CH:33]=[CH:34][C:35](B(O)O)=[CH:36][C:31]=2[N:30]=[CH:29]1>>[CH3:1][O:2][C:3](=[O:26])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([O:25][C:35]5[CH:34]=[CH:33][C:32]6[N:28]([CH3:27])[CH:29]=[N:30][C:31]=6[CH:36]=5)[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1参加物
3
実験手順
The title compound is prepared from {(S)-6-[(R)-7-fluoro-4-hydroxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and (1-methyl-1H-benzimidazol-5-yl)boronic acid following a procedure analogous to that described for Intermediate 6. LC (method 7): tR=0.36 min; Mass spectrum (ESI+): m/z=489 [M+H]+.
出典と根拠
- ORDレコード
- ord-fb6105b812ad4c3484b52537bd4329a3
- 出典データセット
- uspto-grants-2014_08