化工社化工社 化学情報印刷レポート · 研究参考用
2-Chloro-5-nitropyridin-4-amine → 6-Chloropyridine-3,4-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-5-nitropyridin-4-amine | HCID 10910058 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 6-Chloropyridine-3,4-diamine | HCID 817133 | 107.4% |
反応手順
To a solution of 2-chloro-5-nitropyridin-4-amine (4.50 g, 25.93 mmol) in EtOAc (100 mL) was added Raney nickel (0.45 g) followed by stirring under hydrogen at RT for 2 h. The reaction mixture was filtered and the filtrate concentrated under reduced pressure to afford 4.00 g (ca. 100%) of crude 6-chloropyridine-3,4-diamine as yellow oil. MS (ESI): m/z=144.3 [M+1]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08815877B2 |
| 出典データセット | uspto-grants-2014_08 |
| ORD ID | ord-6be8b6661d27469f9649a4b31d83a784 |
| 出典メモ | uspto-grants-2014_08 |