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2-Methyl-1H-imidazole-4-carboxaldehyde → (S)-2-Amino-6-{2-fluoro-5-[(2-methyl-3H-imidazol-4-ylmethyl)-amino]-phenyl}-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methyl-1H-imidazole-4-carboxaldehyde | HCID 2795878 | — |
| 反応物 | (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one | HCID 57497157 | — |
| 反応物 | HCID 178419135 | HCID 178419135 | — |
| 生成物 | (S)-2-Amino-6-{2-fluoro-5-[(2-methyl-3H-imidazol-4-ylmethyl)-amino]-phenyl}-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one | HCID 57497081 | — |
反応手順
The reductive amination of (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate J) and 2-methyl-3H-imidazole-4-carbaldehyde using decaborane yielded the title compound as a white solid. MS (ESI): m/z=373.2 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08815881B2 |
| 出典データセット | uspto-grants-2014_08 |
| ORD ID | ord-af97d473a6384e9fa054a926d8aa7400 |
| 出典メモ | uspto-grants-2014_08 |