6-(2,2,2-Trifluoroethoxy)pyridin-3-amine → (S)-2-Amino-6-(2-fluoro-5-(6-(2,2,2-trifluoroethoxy)pyridin-3-ylamino)phenyl)-3,5,5,6-tetramethyl-5,6-dihydropyrimidin-4(3H)-one
反応式
COC1C=CC(C([NH:24][C:25]2[N:30]([CH3:31])[C:29](=[O:32])[C:28]([CH3:34])([CH3:33])[C@:27]([C:36]3[CH:41]=[C:40](Br)[CH:39]=[CH:38][C:37]=3[F:43])([CH3:35])[N:26]=2)(C2C=CC(OC)=CC=2)C2C=CC=CC=2)=CC=1.[F:44][C:45]([F:56])([F:55])[CH2:46][O:47][C:48]1[N:53]=[CH:52][C:51]([NH2:54])=[CH:50][CH:49]=1>>[NH2:24][C:25]1[N:30]([CH3:31])[C:29](=[O:32])[C:28]([CH3:34])([CH3:33])[C@:27]([C:36]2[CH:41]=[C:40]([NH:54][C:51]3[CH:52]=[N:53][C:48]([O:47][CH2:46][C:45]([F:44])([F:55])[F:56])=[CH:49][CH:50]=3)[CH:39]=[CH:38][C:37]=2[F:43])([CH3:35])[N:26]=1参加物
3
反応物 2
生成物 1
実験手順
The coupling of (S)-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-6-(5-bromo-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate K) and 6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine according to procedure B followed by deprotection yielded the title compound as an off-white foam. MS (ESI): m/z=454.2 [M+H]+.