1-(Prop-2-en-1-yl)cyclopropane-1-sulfonyl chloride → 1-Allyl-cyclopropanesulfonic acid [3,4,6-trifluoro-2-(2-fluoro-4-iodo-phenylamino)phenyl]-amide

HRID 240964

反応式

HRID 240964 の反応式
[CH2:1]([C:4]1([S:7](Cl)(=[O:9])=[O:8])[CH2:6][CH2:5]1)[CH:2]=[CH2:3].[F:11][C:12]1[CH:17]=[C:16]([F:18])[C:15]([F:19])=[C:14]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([I:27])=[CH:23][C:22]=2[F:28])[C:13]=1[NH2:29]>>[F:19][C:15]1[C:14]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([I:27])=[CH:23][C:22]=2[F:28])=[C:13]([NH:29][S:7]([C:4]2([CH2:1][CH:2]=[CH2:3])[CH2:6][CH2:5]2)(=[O:9])=[O:8])[C:12]([F:11])=[CH:17][C:16]=1[F:18]

参加物

3

反応物 2

HCID 441819591-(Prop-2-en-1-yl)cyclopropane-1-sulfonyl chlorideHCID 593863433,5,6-trifluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine

生成物 1

HCID 576266441-Allyl-cyclopropanesulfonic acid [3,4,6-trifluoro-2-(2-fluoro-4-iodo-phenylamino)phenyl]-amide

実験手順

According to the general procedure B, 1-allyl-cyclopropanesulfonyl chloride was reacted with 3,5,6-trifluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine to obtain the title product. 1H NMR (CDCl3, 300 MHz): δ 7.41 (dd, 1H), 7.38 (dd, 1H), 7.09 (s, 1H), 6.78 (m, 1H), 6.49 (m, 1H), 5.96 (s, 1H), 5.86 (m, 1H), 5.18 (d, 2H), 2.76 (d, 2H), 1.23 (m, 2H), 0.872 (m, 2H).

出典と根拠

ORDレコード
ord-bc4f5166768c41a8a2e0112d9e6bdad5
出典データセット
uspto-grants-2014_02
特許番号
US08648116B2

関連ノート

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