化工社化工社 化学情報印刷レポート · 研究参考用
4,6-Dichloro-5-methylpyrimidine → 4-Chloro-5-methyl-6-(phenylmethyl)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,6-Dichloro-5-methylpyrimidine | HCID 818860 | — |
| 反応物 | HCID 178419772 | HCID 178419772 | — |
| 生成物 | 4-Chloro-5-methyl-6-(phenylmethyl)pyrimidine | HCID 86647810 | — |
反応手順
Prepared from 4,6-dichloro-5-methylpyrimidine and benzyl zinc bromide (0.5 M solution in tetrahydrofuran) according to the procedure described in WO 2007/146824 as a colorless oil. 1H NMR (400 MHz, CDCl3): 8.78 (s, 1H), 7.33-7.18 (m, 5H), 4.19 (s, 2H), 2.36 (s, 3H); MS (EI) for C12H11ClN2: 219 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08648066B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-99aad49d6c514068be450f3affc03e1c |
| 出典メモ | uspto-grants-2014_02 |