Methyl 1-formylcyclopentanecarboxylate → Methyl 1-{[4-({[4-(tetrahydro-2H-pyran-4-yloxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]-methyl}cyclopentanecarboxylate

反応式

[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][O:8][C:9]2[C:13]3[C:14]([O:18][CH:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)=[CH:15][CH:16]=[CH:17][C:12]=3[O:11][N:10]=2)[CH2:3][CH2:2]1.[CH:25]([C:27]1([C:32]([O:34][CH3:35])=[O:33])[CH2:31][CH2:30][CH2:29][CH2:28]1)=O.C(C1(C(OC)=O)CCC1)=O>>[O:22]1[CH2:23][CH2:24][CH:19]([O:18][C:14]2[C:13]3[C:9]([O:8][CH2:7][CH:4]4[CH2:3][CH2:2][N:1]([CH2:25][C:27]5([C:32]([O:34][CH3:35])=[O:33])[CH2:31][CH2:30][CH2:29][CH2:28]5)[CH2:6][CH2:5]4)=[N:10][O:11][C:12]=3[CH:17]=[CH:16][CH:15]=2)[CH2:20][CH2:21]1

参加物

反応物 3

HCID 10931680Methyl 1-formylcyclopentanecarboxylate

HCID 15656335Methyl 1-formylcyclobutane-1-carboxylate

HCID 693164473-(Piperidin-4-ylmethoxy)-4-(tetrahydro-2H-pyran-4-yloxy)-1,2-benzisoxazole

生成物 1

HCID 69316175Methyl 1-{[4-({[4-(tetrahydro-2H-pyran-4-yloxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]-methyl}cyclopentanecarboxylate

実験手順

The title compound was prepared according to the procedure described in Step 3 of EXAMPLE 2 using 3-(piperidin-4-ylmethoxy)-4-(tetrahydro-2H-pyran-4-yloxy)-1,2-benzisoxazole (EXAMPLE 27, Step 1) and methyl 1-formylcyclopentanecarboxylate (Synthesis, 1997, 32) instead of 3-(piperidin-4-ylmethoxy)-4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazole and methyl 1-formylcyclobutanecarboxylate.