Cetyl Alcohol → Cetyl Myristoleate

HRID 2410627

反応式

HRID 2410627 の反応式
[CH2:1]([OH:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]>CCCCCC>[C:1]([O:17][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH3:14]

参加物

3

反応物 1

HCID 2682Cetyl Alcohol

生成物 1

HCID 6443825Cetyl Myristoleate収率 90%

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

cis-9-Myristoleate, 3 (4.2 g, 0.0175 mol) was enzymatically transesterified with cetyl alcohol (5.08 g, 0.021 mol) in the presence of Novozyme 435 (0.930 g, 10 wt % of the total substrate) at 68° C. for 8 hr. The reaction was monitored by TLC and after completion of the reaction, hexane (50 ml) was added and the lipase was separated by filtration and the solvent was evaporated to get the crude product and was purified by column chromatography to obtain hexadecyl cis-9-tetradecenoate, 4 (7.48 g, 0.0166 mol) in 90% yield with 90% purity by GC. The structure of hexadecyl cis-9-tetradecenoate, 4 was confirmed by 1H NMR, IR, and GC-MS.

後処理

  1. customat 68° C.
  2. customfor 8 hr
  3. additionwas added
  4. customthe lipase was separated by filtration
  5. customthe solvent was evaporated
  6. customto get the crude product
  7. customwas purified by column chromatography

出典と根拠

ORDレコード
ord-e453da16b0694da4add7501e0fe3f6a9
出典データセット
uspto-grants-2014_08
特許番号
US08816109B2

関連ノート

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