Ammonia → 2-Amino-5-bromopyridine-3-sulfonamide
反応式
[NH2:1][C:2]1[C:7]([S:8](Cl)(=[O:10])=[O:9])=[CH:6][C:5]([Br:12])=[CH:4][N:3]=1.[NH3:13]>O1CCOCC1>[NH2:1][C:2]1[C:7]([S:8]([NH2:13])(=[O:10])=[O:9])=[CH:6][C:5]([Br:12])=[CH:4][N:3]=1参加物
4
実験手順
2-Amino-5-bromopyridine-3-sulfonyl chloride (reagent preparation 25) (95.5 mg, 0.35 mmol) was treated with 0.5M ammonia in dioxane solution (7 mL) and the mixture was stirred for 1 h at room temperature. Concentrated aqueous ammonia (2 mL) was then added to the mixture then stirred an additional 12 h. The mixture was then concentrated and the residue suspended in water (5 mL). The solid was collected by filtration and dried to give 2-amino-5-bromopyridine-3-sulfonamide (55.7 mg, 89%).
後処理
- stirringthen stirred an additional 12 h
- concentrationThe mixture was then concentrated
- filtrationThe solid was collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-e5320d8f4f554ff1ad962cc3902c6112
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08648066B2
反応ノート
読み込み中…