3-Chloropropanesulphonyl chloride → 4-(1,1-Dioxo-1,2-thiazolidin-2-yl)-3-methylbenzoic acid

HRID 2411142ノート

反応式

HRID 2411142 の反応式
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[CH:4][C:3]=1[CH3:13].Cl[CH2:15][CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19]>>[O:19]=[S:18]1(=[O:20])[CH2:17][CH2:16][CH2:15][N:1]1[C:2]1[CH:12]=[CH:11][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[CH3:13]

参加物

3

反応物 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 282796Ethyl 4-amino-3-methylbenzoate

生成物 1

HCID 246888114-(1,1-Dioxo-1,2-thiazolidin-2-yl)-3-methylbenzoic acid

実験手順

Using ethyl 4-amino-3-methylbenzoate (1.0 g) and 3-chloropropane-1-sulfonyl chloride (0.9 mL) and by the reaction and treatment in the same manner as in Preparation Example 16, the title compound (463 mg) was obtained.

後処理

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 16

出典と根拠

ORDレコード
ord-13508518d12d42488b2cf3d74a89d3ae
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

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