Benzoyl chloride → 3-Benzoyl-1-(4-methoxybenzyl)-4,4-dimethylimidazolidin-2-one

反応式

[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][N:8]2[CH2:12][C:11]([CH3:14])([CH3:13])[NH:10][C:9]2=[O:15])=[CH:5][CH:4]=1.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:18]([N:10]1[C:11]([CH3:14])([CH3:13])[CH2:12][N:8]([CH2:7][C:6]2[CH:16]=[CH:17][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[C:9]1=[O:15])(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

反応物 2

HCID 7412Benzoyl chloride

HCID 712526731-(4-Methoxybenzyl)-4,4-dimethylimidazolidin-2-one

生成物 1

HCID 712524583-Benzoyl-1-(4-methoxybenzyl)-4,4-dimethylimidazolidin-2-one

実験手順

Using 1-(4-methoxybenzyl)-4,4-dimethylimidazolidin-2-one (500 mg) described in Preparation Example 54 and benzoyl chloride (0.28 mL) and by the reaction and treatment in the same manner as in Preparation Example 55, the title compound (500 mg) was obtained.

出典と根拠

ORDレコード: ord-053d771d665f4303b5198a9b5b988547
出典データセット: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08816079B2

反応ノート

読み込み中…