Methanesulfonyl chloride → methyl (S)-4-(1-methanesulfonylaminoethyl)benzoate

反応式

[NH2:1][C@H:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)[CH3:3].[CH3:14][S:15](Cl)(=[O:17])=[O:16]>>[CH3:14][S:15]([NH:1][C@H:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)[CH3:3])(=[O:17])=[O:16]

参加物

反応物 2

HCID 31297Methanesulfonyl chloride

HCID 17751895Methyl 4-((1S)-1-aminoethyl)benzoate

生成物 1

HCID 71262918methyl (S)-4-(1-methanesulfonylaminoethyl)benzoate

実験手順

Using methyl (S)-4-(1-aminoethyl)benzoate (0.61 g) and methanesulfonyl chloride (0.29 mL) and by the reaction and treatment in the same manner as in Preparation Example 71, the title compound (0.81 g) was obtained.

後処理

customby the reaction and treatment in the same manner
customas in Preparation Example 71

出典と根拠

ORDレコード: ord-fb924fb53f7e423d92e701fbc088fc69
出典データセット: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08816079B2

反応ノート

読み込み中…

参加物