N,N-bis(2-chloroethyl)-p-toluenesulphonamide → 1-(4-Methyl-2-trifluoromethylphenyl)piperazine

HRID 2411228ノート

反応式

HRID 2411228 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:3]=1.Cl[CH2:14][CH2:15][N:16]([CH2:27][CH2:28]Cl)S(C1C=CC(C)=CC=1)(=O)=O>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:28][CH2:27][NH:16][CH2:15][CH2:14]2)=[C:4]([C:9]([F:10])([F:11])[F:12])[CH:3]=1

参加物

3

反応物 2

HCID 96039N,N-bis(2-chloroethyl)-p-toluenesulphonamideHCID 27377104-Methyl-2-(trifluoromethyl)aniline

生成物 1

HCID 213638351-(4-Methyl-2-trifluoromethylphenyl)piperazine収率 26.4%

実験手順

Using 4-methyl-2-trifluoromethylphenylamine (1 g) and N,N-bis(2-chloroethyl)-p-toluenesulfonamide (1.69 g) and by the reaction and treatment in the same manner as in Preparation Example 95, the title compound (368 mg) was obtained.

後処理

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 95

出典と根拠

ORDレコード
ord-7ae19ebd6fbd4d77aceb3d0a2b2ca217
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

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