4-Bromo-2-fluorobenzoyl chloride → (4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2411259ノート

反応式

HRID 2411259 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[C:4]([F:11])[CH:3]=1.Cl.[CH3:13][C:14]1[C:15]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[N:16][C:17]([CH3:21])=[C:18]([CH3:20])[CH:19]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:25]2[CH2:26][CH2:27][N:22]([C:15]3[C:14]([CH3:13])=[CH:19][C:18]([CH3:20])=[C:17]([CH3:21])[N:16]=3)[CH2:23][CH2:24]2)=[O:7])=[C:4]([F:11])[CH:3]=1

参加物

3

反応物 2

HCID 27340264-Bromo-2-fluorobenzoyl chlorideHCID 673810521-(3,5,6-Trimethylpyridin-2-yl)piperazine hydrochloride

生成物 1

HCID 58484847(4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone収率 59.5%

実験手順

Using 4-bromo-2-fluorobenzoyl chloride (5 g) and 1-(3,5,6-trimethylpyridin-2-yl)piperazine hydrochloride (5 g) described in Preparation Example 91 and by the reaction and treatment in the same manner as in Preparation Example 108, the title compound (5 g) was obtained.

後処理

  1. customdescribed in Preparation Example 91 and by the reaction and treatment in the same manner as in Preparation Example 108

出典と根拠

ORDレコード
ord-ad0e3972d124424fad6ecec92825a17c
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…