1-(5-Bromo-3-methylpyridin-2-yl)piperazine → HCID 58484740、化合物

反応式

[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[Br:12][C:13]1[CH:14]=[C:15]([CH3:25])[C:16]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:17][CH:18]=1>>[Br:12][C:13]1[CH:14]=[C:15]([CH3:25])[C:16]([N:19]2[CH2:20][CH2:21][N:22]([C:6]([C:5]3[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=3[CH3:11])=[O:8])[CH2:23][CH2:24]2)=[N:17][CH:18]=1

参加物

反応物 2

HCID 467392701-(5-Bromo-3-methylpyridin-2-yl)piperazine

HCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acid

生成物 1

HCID 58484740HCID 58484740、化合物収率 86.8%

実験手順

Using 6-fluoro-4-methylnicotinic acid (1.00 g) and 1-(5-bromo-3-methylpyridin-2-yl)piperazine (1.65 g) and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (2.20 g) was obtained.

後処理

customby the reaction and treatment in the same manner
customas in Preparation Example 111

出典と根拠

ORDレコード: ord-fab4b36cb0cd42b9b664d2b8db0c9d9a
出典データセット: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08816079B2

反応ノート

読み込み中…

参加物