1-(2,4-Xylyl)piperazine → (4-Amino-2-trifluoromethylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

HRID 2411281ノート

反応式

HRID 2411281 の反応式
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=O)=[C:6]([C:13]([F:16])([F:15])[F:14])[CH:5]=1)([O-])=O.[CH3:17][C:18]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:19]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[NH2:1][C:4]1[CH:12]=[CH:11][C:7]([C:8]([N:28]2[CH2:29][CH2:30][N:25]([C:19]3[CH:20]=[CH:21][C:22]([CH3:24])=[CH:23][C:18]=3[CH3:17])[CH2:26][CH2:27]2)=[O:10])=[C:6]([C:13]([F:16])([F:15])[F:14])[CH:5]=1

参加物

3

反応物 2

HCID 705441-(2,4-Xylyl)piperazineHCID 27827374-Nitro-2-(trifluoromethyl)benzoic acid

生成物 1

HCID 86676758(4-Amino-2-trifluoromethylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone収率 106.3%

実験手順

Using 4-nitro-2-trifluoromethylbenzoic acid (500 mg) and 1-(2,4-dimethylphenyl)piperazine (403 mg) and by the reaction and treatment in the same manner as in Preparation Example 148, the title compound (850 mg) was obtained.

後処理

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 148

出典と根拠

ORDレコード
ord-a0489e466a9349c3a9e8ff44c57850b1
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…