4-Bromobenzoyl chloride → (4-Bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

HRID 2411306ノート

反応式

HRID 2411306 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:22]2[CH2:23][CH2:24][N:19]([C:13]3[CH:14]=[CH:15][C:16]([CH3:18])=[CH:17][C:12]=3[CH3:11])[CH2:20][CH2:21]2)=[O:7])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 685154-Bromobenzoyl chlorideHCID 705441-(2,4-Xylyl)piperazine

生成物 1

HCID 58484623(4-Bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone収率 72.9%

実験手順

Using 4-bromobenzoyl chloride (25 g) and 1-(2,4-dimethylphenyl)piperazine (22 g) and by the reaction and treatment in the same manner as in Preparation Example 108, the title compound (31 g) was obtained.

後処理

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 108

出典と根拠

ORDレコード
ord-c83b198c976a425595a535bf355a1454
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

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