6-Fluoro-4-methylpyridine-3-carboxylic acid → [4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone

HRID 2411314ノート

反応式

HRID 2411314 の反応式
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH:12]1([C:15]2[C:16]([N:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)=[N:17][CH:18]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:20]=2)[CH2:14][CH2:13]1>>[CH:12]1([C:15]2[C:16]([N:24]3[CH2:25][CH2:26][N:27]([C:6]([C:5]4[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=4[CH3:11])=[O:8])[CH2:28][CH2:29]3)=[N:17][CH:18]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:20]=2)[CH2:13][CH2:14]1

参加物

3

反応物 2

HCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acidHCID 584847011-(3,5-Dicyclopropylpyridin-2-yl)piperazine

生成物 1

HCID 58484583[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone収率 85.5%

実験手順

Using 6-fluoro-4-methylnicotinic acid (0.60 g) and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine (0.92 g) described in Preparation Example 88 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (1.23 g) was obtained.

後処理

  1. customdescribed in Preparation Example 88 and by the reaction and treatment in the same manner as in Preparation Example 111

出典と根拠

ORDレコード
ord-fa192ea190e34de99eac0f8f12d02be3
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…