6-Fluoro-4-methylpyridine-3-carboxylic acid → HCID 58484588、化合物

HRID 2411315ノート

反応式

HRID 2411315 の反応式
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH:12]1([C:15]2[CH:20]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:18]=[CH:17][C:16]=2[N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:14][CH2:13]1>>[CH:12]1([C:15]2[CH:20]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:18]=[CH:17][C:16]=2[N:24]2[CH2:25][CH2:26][N:27]([C:6]([C:5]3[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=3[CH3:11])=[O:8])[CH2:28][CH2:29]2)[CH2:13][CH2:14]1

参加物

3

反応物 2

HCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acidHCID 67381204HCID 67381204、化合物

生成物 1

HCID 58484588HCID 58484588、化合物収率 103.8%

実験手順

Using 6-fluoro-4-methylnicotinic acid (386 mg) and 1-(2,4-dicyclopropylphenyl)piperazine (650 mg) described in Preparation Example 101 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (980 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 101 and by the reaction and treatment in the same manner as in Preparation Example 118

出典と根拠

ORDレコード
ord-2857f953ab9e4c88a45d7b07ef7bb419
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…