6-Bromonicotinic acid → 2-[4-(6-Bromopyridine-3-carbonyl)piperazin-1-yl]-5-methylnicotinonitrile

HRID 2411320ノート

反応式

HRID 2411320 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[C:11]([C:13]1[C:14]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=1)#[N:12]>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[N:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=3[C:11]#[N:12])[CH2:21][CH2:22]2)=[O:8])=[CH:9][CH:10]=1

参加物

3

反応物 2

HCID 2389326-Bromonicotinic acidHCID 712522894-(3-Cyano-5-methylpyridin-2-yl)piperazine

生成物 1

HCID 866767642-[4-(6-Bromopyridine-3-carbonyl)piperazin-1-yl]-5-methylnicotinonitrile収率 79.2%

実験手順

Using 6-bromonicotinic acid (303 mg) and 4-(3-cyano-5-methylpyridin-2-yl)piperazine (303 mg) described in Preparation Example 107 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (458 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 107 and by the reaction and treatment in the same manner as in Preparation Example 111

出典と根拠

ORDレコード
ord-7eac7b0eb0344ceead57a10fd8a1d035
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…