1-(2,4-Xylyl)piperazine → HCID 71251979、化合物

反応式

[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([C:11]#[N:12])[CH:3]=1.[CH3:13][C:14]1[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:15]=1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:24]2[CH2:25][CH2:26][N:21]([C:15]3[CH:16]=[CH:17][C:18]([CH3:20])=[CH:19][C:14]=3[CH3:13])[CH2:22][CH2:23]2)=[O:8])=[C:4]([CH:3]=1)[C:11]#[N:12]

参加物

反応物 2

HCID 705441-(2,4-Xylyl)piperazine

HCID 584845854-Bromo-2-cyanobenzoic acid

生成物 1

HCID 71251979HCID 71251979、化合物収率 84%

実験手順

Using 4-bromo-2-cyanobenzoic acid (1.81 g) described in Preparation Example 76 and 1-(2,4-dimethylphenyl)piperazine (1.67 g) and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (2.68 g) was obtained.

出典と根拠

ORDレコード: ord-334e8fdfb2904a828fe609cd0c11e370
出典データセット: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08816079B2

反応ノート

読み込み中…