6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2411339ノート

反応式

HRID 2411339 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:11][C:12]1[C:13]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:14][C:15]([CH3:19])=[C:16]([CH3:18])[CH:17]=1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:13]3[C:12]([CH3:11])=[CH:17][C:16]([CH3:18])=[C:15]([CH3:19])[N:14]=3)[CH2:21][CH2:22]2)=[O:8])=[CH:9][CH:10]=1

参加物

3

反応物 2

HCID 2389326-Bromonicotinic acidHCID 584848231-(3,5,6-Trimethylpyridin-2-yl)piperazine

生成物 1

HCID 58484612(6-Bromopyridin-3-yl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone収率 88.2%

実験手順

Using 6-bromonicotinic acid (606 mg) and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (616 mg) described in Preparation Example 92 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (1.03 g) was obtained.

後処理

  1. customdescribed in Preparation Example 92 and by the reaction and treatment in the same manner as in Preparation Example 111

出典と根拠

ORDレコード
ord-2ccb286a626c4aabbb35484de828acdc
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

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