1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 86676765、化合物

HRID 2411355ノート

反応式

HRID 2411355 の反応式
[Br:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:12][C:13]1[C:14]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[C:13]([CH3:12])=[CH:18][C:17]([CH3:19])=[CH:16][N:15]=3)[CH2:21][CH2:22]2)=[O:8])=[C:9]([CH3:11])[CH:10]=1

参加物

3

反応物 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 722121586-Bromo-4-methyl-3-pyridinecarboxylic acid

生成物 1

HCID 86676765HCID 86676765、化合物収率 97.7%

実験手順

Using 6-bromo-4-methylnicotinic acid (500 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (443 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (880 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 111

出典と根拠

ORDレコード
ord-e09ec244a812476aa832513335e741b7
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…