5-Bromopyrazine-2-carboxylic acid → HCID 86676767、化合物

HRID 2411359ノート

反応式

HRID 2411359 の反応式
[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH3:11][C:12]1[C:13]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:14][CH:15]=[C:16]([CH3:18])[CH:17]=1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([N:22]2[CH2:23][CH2:24][N:19]([C:13]3[C:12]([CH3:11])=[CH:17][C:16]([CH3:18])=[CH:15][N:14]=3)[CH2:20][CH2:21]2)=[O:10])=[N:6][CH:7]=1

参加物

3

反応物 2

HCID 187797905-Bromopyrazine-2-carboxylic acidHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

生成物 1

HCID 86676767HCID 86676767、化合物収率 69.5%

実験手順

Using 5-bromopyrazine-2-carboxylic acid (203 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (191 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (261 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118

出典と根拠

ORDレコード
ord-ebbee38ada434d988d5ef2b3a423fe0b
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…