4-(2,6,6-Trimethyl-5,6,7,8-tetrahydroquinazolin-4-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-7-ylboronic acid → N-ethyl-6-[4-(2,6,6-trimethyl-5,6,7,8-tetrahydroquinazolin-4-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-1H-imidazo[4,5-b]pyridin-2-amine

HRID 241136

反応式

HRID 241136 の反応式
Br[C:2]1[CH:3]=[C:4]2[N:10](COC)[C:9]([NH:14][CH2:15][CH3:16])=[N:8][C:5]2=[N:6][CH:7]=1.[CH3:17][C:18]1[N:27]=[C:26]([N:28]2[CH2:34][C:33]3[CH:35]=[C:36](B(O)O)[CH:37]=[CH:38][C:32]=3[O:31][CH2:30][CH2:29]2)[C:25]2[CH2:24][C:23]([CH3:43])([CH3:42])[CH2:22][CH2:21][C:20]=2[N:19]=1>>[CH2:15]([NH:14][C:9]1[NH:10][C:4]2[C:5]([N:8]=1)=[N:6][CH:7]=[C:2]([C:36]1[CH:37]=[CH:38][C:32]3[O:31][CH2:30][CH2:29][N:28]([C:26]4[C:25]5[CH2:24][C:23]([CH3:42])([CH3:43])[CH2:22][CH2:21][C:20]=5[N:19]=[C:18]([CH3:17])[N:27]=4)[CH2:34][C:33]=3[CH:35]=1)[CH:3]=2)[CH3:16]

参加物

3

反応物 2

HCID 668200184-(2,6,6-Trimethyl-5,6,7,8-tetrahydroquinazolin-4-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-7-ylboronic acidHCID 668205496-bromo-N-ethyl-1-[(methyloxy)methyl]-1H-imidazo[4,5-b]pyridin-2-amine

生成物 1

HCID 59586297N-ethyl-6-[4-(2,6,6-trimethyl-5,6,7,8-tetrahydroquinazolin-4-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-1H-imidazo[4,5-b]pyridin-2-amine

実験手順

Prepared according to the method of example 5 by using 6-bromo-N-ethyl-1-[(methyloxy)methyl]-1H-imidazo[4,5-b]pyridin-2-amine (reagent preparation 36) and [4-(2,6,6-trimethyl-5,6,7,8-tetrahydroquinazolin-4-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]boronic acid (reagent preparation 23) in step 1 followed by MOM deprotection. 1H NMR (400 MHz, methanol-d4): 8.15 (d, 1H), 7.64 (d, 1H), 7.55 (d, 1H), 7.43 (dd, 1H), 7.06 (d, 1H), 4.71 (s, 2H), 4.31 (m, 2H), 3.99 (m, 2H), 3.46 (q, 2H), 2.75 (t, 2H), 2.47 (s, 2H), 2.41 (s, 3H), 1.66 (t, 2H), 1.30 (t, 3H), 0.91 (s, 6H); MS (EI) for C27H30N6O: 455 (MH+).

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-92a0935a6a5a46c3a53c6836a9edbadf
出典データセット
uspto-grants-2014_02
特許番号
US08648066B2

関連ノート

読み込み中…