5-Bromopyrazine-2-carboxylic acid → HCID 86676769、化合物

HRID 2411370ノート

反応式

HRID 2411370 の反応式
[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH:11]1([C:14]2[CH:15]=[C:16]([CH3:26])[C:17]([N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)=[N:18][CH:19]=2)[CH2:13][CH2:12]1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([N:23]2[CH2:24][CH2:25][N:20]([C:17]3[C:16]([CH3:26])=[CH:15][C:14]([CH:11]4[CH2:12][CH2:13]4)=[CH:19][N:18]=3)[CH2:21][CH2:22]2)=[O:10])=[N:6][CH:7]=1

参加物

3

反応物 2

HCID 187797905-Bromopyrazine-2-carboxylic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

生成物 1

HCID 86676769HCID 86676769、化合物収率 65.6%

実験手順

Using 5-bromopyrazine-2-carboxylic acid (1 g) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (1.07 g) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (1.3 g) was obtained.

後処理

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 118

出典と根拠

ORDレコード
ord-b7b2fca0d1164dc8ab30fd4099a47bfa
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…