2-amino-5-bromo-N,N-dimethylpyridine-3-sulfonamide → 2-amino-N,N-dimethyl-5-[4-(2,6,6-trimethyl-5,6,7,8-tetrahydroquinazolin-4-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]pyridine-3-sulfonamide

HRID 241138

反応式

HRID 241138 の反応式
[CH3:1][C:2]1[N:11]=[C:10]([N:12]2[CH2:18][C:17]3[CH:19]=[C:20](B(O)O)[CH:21]=[CH:22][C:16]=3[O:15][CH2:14][CH2:13]2)[C:9]2[CH2:8][C:7]([CH3:27])([CH3:26])[CH2:6][CH2:5][C:4]=2[N:3]=1.[NH2:28][C:29]1[C:34]([S:35]([N:38]([CH3:40])[CH3:39])(=[O:37])=[O:36])=[CH:33][C:32](Br)=[CH:31][N:30]=1>>[NH2:28][C:29]1[C:34]([S:35]([N:38]([CH3:40])[CH3:39])(=[O:37])=[O:36])=[CH:33][C:32]([C:20]2[CH:21]=[CH:22][C:16]3[O:15][CH2:14][CH2:13][N:12]([C:10]4[C:9]5[CH2:8][C:7]([CH3:27])([CH3:26])[CH2:6][CH2:5][C:4]=5[N:3]=[C:2]([CH3:1])[N:11]=4)[CH2:18][C:17]=3[CH:19]=2)=[CH:31][N:30]=1

参加物

3

反応物 2

HCID 523351532-amino-5-bromo-N,N-dimethylpyridine-3-sulfonamideHCID 668200184-(2,6,6-Trimethyl-5,6,7,8-tetrahydroquinazolin-4-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-7-ylboronic acid

生成物 1

HCID 595861192-amino-N,N-dimethyl-5-[4-(2,6,6-trimethyl-5,6,7,8-tetrahydroquinazolin-4-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]pyridine-3-sulfonamide

実験手順

Prepared according to the method of example 5 by using 4-(2,6,6-trimethyl-5,6,7,8-tetrahydroquinazolin-4-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-7-ylboronic acid (reagent preparation 23) and 2-amino-5-bromo-N,N-dimethylpyridine-3-sulfonamide (reagent preparation 25) in step 1. 1H NMR (400 MHz, methanol-d4): 8.47 (s, 1H), 8.04 (s, 1H), 7.52 (s, 1H), 7.41 (d, 1H), 7.06 (d, 1H), 4.71 (s, 2H), 4.31 (m, 2H), 4.00 (m, 2H), 2.80 (s, 6H), 2.75 (m, 2H), 2.45 (s, 2H), 2.40 (s, 3H), 1.67 (m, 2H), 0.91 (s, 6H); MS (EI) for C27H34N6O3S: 523 (MH+).

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-84436d630ea14cc6b0f1e1662fb56fe1
出典データセット
uspto-grants-2014_02
特許番号
US08648066B2

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