3,5-Dimethyl-2,4-Imidazolidinedione → Methyl 6-(3,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-methylnicotinate

反応式

Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH3:12])[N:3]=1.[CH3:13][N:14]1[C:18](=[O:19])[CH:17]([CH3:20])[NH:16][C:15]1=[O:21]>>[CH3:13][N:14]1[C:18](=[O:19])[CH:17]([CH3:20])[N:16]([C:2]2[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH3:12])[N:3]=2)[C:15]1=[O:21]

参加物

反応物 2

HCID 101540613,5-Dimethyl-2,4-Imidazolidinedione

HCID 71691566Methyl 6-bromo-2-methylpyridine-3-carboxylate

生成物 1

HCID 71252642Methyl 6-(3,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-methylnicotinate収率 16.4%

実験手順

Using methyl 6-bromo-2-methylnicotinate (96 mg) and 3,5-dimethylimidazolidine-2,4-dione (107 mg) described in Preparation Example 217 and by the reaction and treatment in the same manner as in Preparation Example 48, the title compound (19 mg) was obtained.

後処理

customdescribed in Preparation Example 217 and by the reaction and treatment in the same manner as in Preparation Example 48

出典と根拠

ORDレコード: ord-c55045bd276a4ea2bea0320410589f0a
出典データセット: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08816079B2

反応ノート

読み込み中…

参加物