[4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone → HCID 71252895、化合物

HRID 2411453ノート

反応式

HRID 2411453 の反応式
[CH3:1][CH:2]1[CH2:6][S:5](=[O:8])(=[O:7])[NH:4][CH2:3]1.[CH2:9]([C:11]1[CH:12]=[C:13]([CH3:32])[C:14]([N:17]2[CH2:22][CH2:21][N:20]([C:23]([C:25]3[CH:30]=[CH:29][C:28](I)=[CH:27][CH:26]=3)=[O:24])[CH2:19][CH2:18]2)=[N:15][CH:16]=1)[CH3:10]>>[CH2:9]([C:11]1[CH:12]=[C:13]([CH3:32])[C:14]([N:17]2[CH2:18][CH2:19][N:20]([C:23]([C:25]3[CH:30]=[CH:29][C:28]([N:4]4[CH2:3][CH:2]([CH3:1])[CH2:6][S:5]4(=[O:8])=[O:7])=[CH:27][CH:26]=3)=[O:24])[CH2:21][CH2:22]2)=[N:15][CH:16]=1)[CH3:10]

参加物

3

反応物 2

HCID 58484605[4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanoneHCID 59155177ZJNXUAJQNBXKSL-UHFFFAOYSA-N

生成物 1

HCID 71252895HCID 71252895、化合物収率 9%

実験手順

Using 4-methylisothiazolidine 1,1-dioxide (202 mg) described in Preparation Example 9 and [4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (500 mg) described in Preparation Example 133 and by the reaction and treatment in the same manner as in Example 1, the title compound (46 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 133 and by the reaction and treatment in the same manner as in Example 1

出典と根拠

ORDレコード
ord-f68693dfeaf54c47932c25b328cdc3ba
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…