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1-(2,4,6-Trimethylphenyl)piperazine → [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)phenyl][4-(2,4,6-trimethylphenyl)piperazin-1-yl]methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2,4,6-Trimethylphenyl)piperazine | HCID 2760822 | — |
| 反応物 | 4-(1,1-Dioxo-1,2-thiazolidin-2-yl)benzoic acid | HCID 6625011 | — |
| 生成物 | [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)phenyl][4-(2,4,6-trimethylphenyl)piperazin-1-yl]methanone | HCID 71252840 | 23% |
反応手順
Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoic acid (253 mg) described in Preparation Example 16 and 1-(2,4,6-trimethylphenyl)piperazine (215 mg) and by the reaction and treatment in the same manner as in Example 87, the title compound (103 mg) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08816079B2 |
| 出典データセット | uspto-grants-2014_08 |
| ORD ID | ord-af5131c153af494fa7170d61c24f4651 |
| 出典メモ | uspto-grants-2014_08 |