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1,3-Propanesultam → [6-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl][4-(p-tolyloxy)piperidin-1-yl]methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Propanesultam | HCID 642157 | — |
| 反応物 | (6-Bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanone | HCID 58484591 | — |
| 生成物 | [6-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl][4-(p-tolyloxy)piperidin-1-yl]methanone | HCID 71252896 | 24.1% |
反応手順
Using (6-bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanone (548 mg) described in Preparation Example 193 and isothiazolidine 1,1-dioxide (177 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (146 mg) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08816079B2 |
| 出典データセット | uspto-grants-2014_08 |
| ORD ID | ord-f66682ffb894410facd9ebf5d49a349b |
| 出典メモ | uspto-grants-2014_08 |