3-Chloropropanesulphonyl chloride → HCID 71251880、化合物

反応式

C1(C2C(N3CCN(C(C4C=NC(F)=CC=4C)=O)CC3)=NC=C(C3CC3)C=2)CC1.COC1C=CC(CN)=CC=1.Cl[CH2:40][CH2:41][CH2:42][S:43](Cl)(=[O:45])=[O:44].[NH2:47][C:48]1[N:53]=[CH:52][C:51]([C:54]([N:56]2[CH2:61][CH2:60][N:59]([C:62]3[C:67]([CH:68]4[CH2:70][CH2:69]4)=[CH:66][C:65]([CH:71]4[CH2:73][CH2:72]4)=[CH:64][N:63]=3)[CH2:58][CH2:57]2)=[O:55])=[C:50]([CH3:74])[CH:49]=1>>[CH:68]1([C:67]2[C:62]([N:59]3[CH2:58][CH2:57][N:56]([C:54]([C:51]4[CH:52]=[N:53][C:48]([N:47]5[CH2:40][CH2:41][CH2:42][S:43]5(=[O:45])=[O:44])=[CH:49][C:50]=4[CH3:74])=[O:55])[CH2:61][CH2:60]3)=[N:63][CH:64]=[C:65]([CH:71]3[CH2:73][CH2:72]3)[CH:66]=2)[CH2:69][CH2:70]1

参加物

反応物 4

HCID 154103-Chloropropanesulphonyl chloride

HCID 754524-Methoxybenzylamine

HCID 58484583[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone

HCID 71252763HCID 71252763、化合物

生成物 1

HCID 71251880HCID 71251880、化合物

実験手順

Using [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone (410 mg) described in Preparation Example 178, 4-methoxybenzylamine (2 mL) and 3-chloropropane-1-sulfonyl chloride (0.24 mL) and by the reaction and treatment in the same manner as in Example 229, the title compound (295 mg) was obtained via (6-amino-4-methylpyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone.

出典と根拠

ORDレコード: ord-4ae20a01665a478ea228ead441bd2273
出典データセット: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08816079B2

反応ノート

読み込み中…