HCID 67381204、化合物 → [4-(2,4-Dicyclopropylphenyl)piperazin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl]methanone

HRID 2411607ノート

反応式

HRID 2411607 の反応式
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=O)=[CH:9][N:8]=1.[CH:19]1([C:22]2[CH:27]=[C:26]([CH:28]3[CH2:30][CH2:29]3)[CH:25]=[CH:24][C:23]=2[N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH2:21][CH2:20]1>>[CH:19]1([C:22]2[CH:27]=[C:26]([CH:28]3[CH2:30][CH2:29]3)[CH:25]=[CH:24][C:23]=2[N:31]2[CH2:32][CH2:33][N:34]([C:11]([C:10]3[CH:9]=[N:8][C:7]([N:3]4[CH2:4][CH2:5][CH2:6][S:2]4(=[O:1])=[O:18])=[CH:17][CH:16]=3)=[O:13])[CH2:35][CH2:36]2)[CH2:20][CH2:21]1

参加物

3

反応物 2

HCID 67381204HCID 67381204、化合物HCID 71251937Ethyl 6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)nicotinate

生成物 1

HCID 71252667[4-(2,4-Dicyclopropylphenyl)piperazin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl]methanone収率 72.4%

実験手順

Using ethyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)nicotinate (300 mg) described in Preparation Example 25 and 1-(2,4-dicyclopropylphenyl)piperazine (296 mg) described in Preparation Example 101 and by the reaction and treatment in the same manner as in Example 109, the title compound (375 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 101 and by the reaction and treatment in the same manner as in Example 109

出典と根拠

ORDレコード
ord-2f2377f3e4c54b60ba47d1d0645a969b
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…