1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71252033、化合物

HRID 2411612ノート

反応式

HRID 2411612 の反応式
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=O)=[C:9]([CH3:17])[N:8]=1.[CH3:19][C:20]1[C:21]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[N:22][CH:23]=[C:24]([CH3:26])[CH:25]=1>>[CH3:19][C:20]1[C:21]([N:27]2[CH2:28][CH2:29][N:30]([C:11]([C:10]3[C:9]([CH3:17])=[N:8][C:7]([N:3]4[CH2:4][CH2:5][CH2:6][S:2]4(=[O:1])=[O:18])=[CH:16][CH:15]=3)=[O:13])[CH2:31][CH2:32]2)=[N:22][CH:23]=[C:24]([CH3:26])[CH:25]=1

参加物

3

反応物 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71252256HCID 71252256、化合物

生成物 1

HCID 71252033HCID 71252033、化合物収率 67.2%

実験手順

Using methyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methylnicotinate (220 mg) described in Preparation Example 37 and 1-(3,5-dimethylpyridin-2-yl)piperazine (186 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (235 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109

出典と根拠

ORDレコード
ord-200a0e8bc4e949c3901168e8c3121671
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…