1-(5-Ethyl-3-methylpyridin-2-yl)piperazine → HCID 71252575、化合物

HRID 2411613ノート

反応式

HRID 2411613 の反応式
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=O)=[C:9]([CH3:17])[N:8]=1.[CH2:19]([C:21]1[CH:22]=[C:23]([CH3:33])[C:24]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[N:25][CH:26]=1)[CH3:20]>>[O:18]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[N:8]=[C:9]([CH3:17])[C:10]([C:11]([N:30]2[CH2:31][CH2:32][N:27]([C:24]3[C:23]([CH3:33])=[CH:22][C:21]([CH2:19][CH3:20])=[CH:26][N:25]=3)[CH2:28][CH2:29]2)=[O:13])=[CH:15][CH:16]=1

参加物

3

反応物 2

HCID 584845781-(5-Ethyl-3-methylpyridin-2-yl)piperazineHCID 71252256HCID 71252256、化合物

生成物 1

HCID 71252575HCID 71252575、化合物収率 5.1%

実験手順

Using methyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methylnicotinate (300 mg) described in Preparation Example 37 and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (251 mg) described in Preparation Example 81 and by the reaction and treatment in the same manner as in Example 109, the title compound (25 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 81 and by the reaction and treatment in the same manner as in Example 109

出典と根拠

ORDレコード
ord-f1716edaabfa4f969169ae9e6915e255
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…