1-(3,5,6-Trimethylpyridin-2-yl)piperazine → HCID 71252165、化合物

HRID 2411614ノート

反応式

HRID 2411614 の反応式
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=O)=[C:9]([CH3:17])[N:8]=1.[CH3:19][C:20]1[C:21]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[N:22][C:23]([CH3:27])=[C:24]([CH3:26])[CH:25]=1>>[O:18]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[N:8]=[C:9]([CH3:17])[C:10]([C:11]([N:31]2[CH2:32][CH2:33][N:28]([C:21]3[C:20]([CH3:19])=[CH:25][C:24]([CH3:26])=[C:23]([CH3:27])[N:22]=3)[CH2:29][CH2:30]2)=[O:13])=[CH:15][CH:16]=1

参加物

3

反応物 2

HCID 584848231-(3,5,6-Trimethylpyridin-2-yl)piperazineHCID 71252256HCID 71252256、化合物

生成物 1

HCID 71252165HCID 71252165、化合物収率 62.4%

実験手順

Using methyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methylnicotinate (300 mg) described in Preparation Example 37 and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (251 mg) described in Preparation Example 92 and by the reaction and treatment in the same manner as in Example 109, the title compound (307 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 92 and by the reaction and treatment in the same manner as in Example 109

出典と根拠

ORDレコード
ord-29052010859745d0b4735caf0d28796a
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

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