1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → HCID 54675480、化合物

HRID 2411615ノート

反応式

HRID 2411615 の反応式
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=O)=[C:9]([CH3:17])[N:8]=1.[CH:19]1([C:22]2[CH:23]=[C:24]([CH3:34])[C:25]([N:28]3[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]3)=[N:26][CH:27]=2)[CH2:21][CH2:20]1>>[CH:19]1([C:22]2[CH:23]=[C:24]([CH3:34])[C:25]([N:28]3[CH2:29][CH2:30][N:31]([C:11]([C:10]4[C:9]([CH3:17])=[N:8][C:7]([N:3]5[CH2:4][CH2:5][CH2:6][S:2]5(=[O:1])=[O:18])=[CH:16][CH:15]=4)=[O:13])[CH2:32][CH2:33]3)=[N:26][CH:27]=2)[CH2:21][CH2:20]1

参加物

3

反応物 2

HCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 71252256HCID 71252256、化合物

生成物 1

HCID 54675480HCID 54675480、化合物収率 58.3%

実験手順

Using methyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methylnicotinate (300 mg) described in Preparation Example 37 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (265 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109, the title compound (295 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109

出典と根拠

ORDレコード
ord-1eaa2a7ea87f4f1e87bd10809d14d37f
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…