1,3-Propanesultam → HCID 71252747、化合物

反応式

Br[C:2]1[CH:3]=[CH:4][C:5]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][C:19]=3[CH3:25])[CH2:14][CH2:13]2)=[O:11])=[C:6]([CH:9]=1)[C:7]#[N:8].[S:26]1(=[O:32])(=[O:31])[CH2:30][CH2:29][CH2:28][NH:27]1>>[CH3:25][C:19]1[CH:20]=[C:21]([CH3:24])[CH:22]=[CH:23][C:18]=1[N:15]1[CH2:16][CH2:17][N:12]([C:10]([C:5]2[CH:4]=[CH:3][C:2]([N:27]3[CH2:28][CH2:29][CH2:30][S:26]3(=[O:32])=[O:31])=[CH:9][C:6]=2[C:7]#[N:8])=[O:11])[CH2:13][CH2:14]1

参加物

反応物 2

HCID 6421571,3-Propanesultam

HCID 71251979HCID 71251979、化合物

生成物 1

HCID 71252747HCID 71252747、化合物収率 91.8%

実験手順

Using 5-bromo-2-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]benzonitrile (797 mg) described in Preparation Example 188 and isothiazolidine 1,1-dioxide (315 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (806 mg) was obtained.

出典と根拠

ORDレコード: ord-316c0bfb0ed8407caa7e993c14f1cf37
出典データセット: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08816079B2

反応ノート

読み込み中…