2-Pyrrolidone → 1-{4-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}pyrrolidin-2-one

HRID 2411676ノート

反応式

HRID 2411676 の反応式
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[CH:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH:29]4[CH2:31][CH2:30]4)=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[C:10]([S:32]([CH3:35])(=[O:34])=[O:33])[CH:9]=1>>[CH:29]1([C:25]2[CH:26]=[C:27]([CH3:28])[C:22]([N:19]3[CH2:20][CH2:21][N:16]([C:14]([C:11]4[CH:12]=[CH:13][C:8]([N:1]5[CH2:5][CH2:4][CH2:3][C:2]5=[O:6])=[CH:9][C:10]=4[S:32]([CH3:35])(=[O:34])=[O:33])=[O:15])[CH2:17][CH2:18]3)=[N:23][CH:24]=2)[CH2:30][CH2:31]1

参加物

3

反応物 2

HCID 120252-PyrrolidoneHCID 58484821(4-Bromo-2-methanesulfonylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

生成物 1

HCID 712520451-{4-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}pyrrolidin-2-one収率 84.6%

実験手順

Using pyrrolidin-2-one (47 mg) and (4-bromo-2-methanesulfonylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (239 mg) described in Preparation Example 126 and by the reaction and treatment in the same manner as in Example 1, the title compound (204 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 126 and by the reaction and treatment in the same manner as in Example 1

出典と根拠

ORDレコード
ord-59808e8bd86e48bc8d341efee507cc41
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…