(S)-5-(Hydroxymethyl)-2-pyrrolidinone → (S)-1-{3-fluoro-4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5-hydroxymethylpyrrolidin-2-one

HRID 2411679ノート

反応式

HRID 2411679 の反応式
[OH:1][CH2:2][C@H:3]1[NH:7][C:6](=[O:8])[CH2:5][CH2:4]1.Br[C:10]1[CH:15]=[CH:14][C:13]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[C:26]([CH3:32])[N:25]=3)[CH2:20][CH2:19]2)=[O:17])=[C:12]([F:33])[CH:11]=1>>[F:33][C:12]1[CH:11]=[C:10]([N:7]2[C@H:3]([CH2:2][OH:1])[CH2:4][CH2:5][C:6]2=[O:8])[CH:15]=[CH:14][C:13]=1[C:16]([N:18]1[CH2:19][CH2:20][N:21]([C:24]2[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[C:26]([CH3:32])[N:25]=2)[CH2:22][CH2:23]1)=[O:17]

参加物

3

反応物 2

HCID 643511(S)-5-(Hydroxymethyl)-2-pyrrolidinoneHCID 58484847(4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

生成物 1

HCID 71252430(S)-1-{3-fluoro-4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5-hydroxymethylpyrrolidin-2-one

実験手順

Using (S)-5-hydroxymethylpyrrolidin-2-one and (4-bromo-2-fluorophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (406 mg) described in Preparation Example 128 and by the reaction and treatment in the same manner as in Example 1, the title compound (171 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 128 and by the reaction and treatment in the same manner as in Example 1

出典と根拠

ORDレコード
ord-8983119f792a42f4a4a64e3b89729438
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…